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Job demands can contribute to stress, burnout, and reduced job satisfactionamong bank workers, adversely affecting their psychological well-being. This studyinvestigated the effects of job demands and musculoskeletal discomfort on the psychologicalwell-being of bank workers in Ibadan, Nigeria. Using a multi-stage sampling method, 394employees from commercial banks completed standardised questionnaires assessing jobdemands, musculoskeletal discomfort, psychological well-being (via Ryff’s Scales), anddemographics. Data were analysed using descriptive statistics, regression, and t-tests.Findings indicated that high job demands significantly impaired psychological well-being (p< .001), accounting for 18% of the variance, whereas musculoskeletal discomfort had noindependent effect (p = .12). A combined model incorporating job demands, musculoskeletaldiscomfort, and age explained 11% of the variance in well-being (p < .001). No significantdifferences were observed by gender or marital status. These results highlight the critical roleof psychosocial factors in Nigeria’s banking sector, where economic pressures exacerbatejob demands. Recommendations include workload management and ergonomic training toenhance employee well-being.