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This study explored the relationship between self-efficacy, religious maturity, and gender as predictors of altruistic behaviour among nurses. A total of 250 nurses from two hospitals in Owerri, Nigeria, participated in the study. The sample consisted of 150 nurses fromthe Federal University Teaching Hospital, Owerri and 100 from the Imo State University Teaching Hospital, Orlu, selected through purposive and convenient sampling techniques. Participants